The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast
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The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast

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The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast

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García Martínez, José; Ayala Gallego, Guillermo; Pelechano García, Vicente José; Chávez, Sebastián; Herrero, Enrique; Pérez Ortín, José Enrique Perfil
Aquest document és un/a article, creat/da en: 2012

Este documento está disponible también en : http://dx.doi.org/10.4161/trns.3.1.19416
It has been recently stated that stress-responding genes in yeast are enriched in cryptic transcripts and that this is the cause of the differences observed between mRNA amount and RNA polymerase occupancy profiles. Other studies have shown that such differences are mainly due to modulation of mRNA stabilities. Here we analyze the relationship between the presence of cryptic transcripts in genes and their stress response profiles. Despite some of the stress-responding gene groups being indeed enriched in specific classes of cryptic transcripts, we found no statistically significant evidence that cryptic transcription is responsible for the differences observed between mRNA and transcription rate profiles.

    García Martínez, José Ayala Gallego, Guillermo Pelechano García, Vicente José Chávez, S. Herrero, E. Pérez Ortín, José Enrique 2012 The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast Transcription 3 1 39 44
http://dx.doi.org/10.4161/trns.3.1.19416
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