Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6
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Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6

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Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6

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Rodríguez Navarro, Susana; Llorente, B.; Rodríguez Manzaneque, M.T.; Ramne, A.; Uber García, Genoveva; Marchesan, D.; Dujon, B.; Herrero, Enrique; Sunnerhagen, P.; Pérez Ortín, José Enrique Perfil
Aquest document és un/a article, creat/da en: 2002
In order to clarify their physiological functions, we have undertaken a characterization of the three-membered gene families SNZ1<br>3 and SNO1<br>3. In media lacking vitamin B6, SNZ1 and SNO1 were both required for growth in certain conditions, but neither SNZ2, SNZ3, SNO2 nor SNO3 were required. Copies 2 and 3 of the gene products have, in spite of their extremely close sequence similarity, slightly different functions in the cell. We have also found that copies 2 and 3 are activated by the lack of thiamine and that the Snz proteins physically interact with the thiamine biosynthesis Thi5 protein family. Whereas copy 1 is required for conditions in which B6 is essential for growth, copies 2 and 3 seem more related with B1 biosynthesis during the exponential phase.

    Rodríguez-Navarro,Susana Llorente, B. Rodríguez-Manzaneque, M.T. Ramne, A. Uber Garcia, Genoveva Marchesan, D. Dujon, B. Herrero, E. Sunnerhagen, P. Pérez-Ortín, José Enrique 2002 Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast 19 1261 1276
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