Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains
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Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains

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Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains

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Pérez Ortín, José Enrique Perfil; Querol Simón, Amparo; Puig Todolí, Sergi; Barrio Esparducer, Eladio
This document is a artículoDate2002

Este documento está disponible también en : http://dx.doi.org/10.1101/gr.436602

Este documento está disponible también en : http://hdl.handle.net/10550/31680
Wine yeast strains show a high level of chromosome length polymorphism. This polymorphism is mainly generated by illegitimate recombination mediated by Ty transposons or subtelomeric repeated sequences. We have found, however, that the SSU1-R allele, which confers sulfite resistance to yeast cells, is the product of a reciprocal translocation between chromosomes VIII and XVI due to unequal crossing-over mediated by microhomology between very short sequences on the 5' upstream regions of the SSU1 and ECM34 genes. We also show that this translocation is only present in wine yeast strains, suggesting that the use for millennia of sulfite as a preservative in wine production could have favored its selection. This is the first time that a gross chromosomal rearrangement is shown to be involved in the adaptive evolution of Saccharomyces cerevisiae.

    Pérez Ortín, José Enrique Querol Simón, Amparo Puig Todolí, Sergi Barrio Esparducer, Eladio 2002 Molecular characterization of a chromosomal rearrangement involved in the adaptative evolution of yeast strains Genome Research 12 10 1533 1539
http://dx.doi.org/10.1101/gr.436602

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