Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors
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Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors

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Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors

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Medina Bessó, Pascual; Segarra Irles, Gloria Vicenta; Mauricio Aviñó, María Dolores Perfil; Vila Salinas, José María; Chuan Nuez, Pascual; Lluch López, Salvador
This document is a artículoDate2010

Este documento está disponible también en : http://hdl.handle.net/10550/31338
The results suggest that charybdotoxin-sensitive, but iberiotoxin-insensitive, K+ channels are activated by stimulation with norepinephrine and electrical field stimulation to counteract the adrenergic-induced contractions of human vas deferens. Thus, inhibition of these channels increases significantly the contraction, an effect that appears to be mediated by an increase in Ca2+ entry through L-type voltage-dependent Ca2+ channels.

    Medina Besso, Pascual Segarra Irles, Gloria Vicenta Mauricio Aviño, María Dolores Vila Salinas, José María Chuan Nuez, Pascual Lluch López, Salvador 2010 Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors Urology 76 6 1518.e7 1518.e12

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