Accumulation of symetric dimethylarginine in hepatorenal syndrome.
NAGIOS: RODERIC FUNCIONANDO

Accumulation of symetric dimethylarginine in hepatorenal syndrome.

DSpace Repository

Accumulation of symetric dimethylarginine in hepatorenal syndrome.

Show simple item record

dc.contributor.author Lluch García, Paloma
dc.contributor.author Mauricio Aviñó, María Dolores
dc.contributor.author Vila Salinas, José María
dc.contributor.author Segarra Irles, Gloria Vicenta
dc.contributor.author Medina Bessó, Pascual
dc.contributor.author Olmo Puchalt, Juan Angel del
dc.contributor.author Rodrigo Gómez, José Manuel
dc.contributor.author Serra Desfilis, Miguel Angel
dc.date.accessioned 2013-11-22T10:58:27Z
dc.date.available 2013-11-22T10:58:27Z
dc.date.issued 2006
dc.identifier.uri http://hdl.handle.net/10550/31336
dc.description.abstract In patients with cirrhosis, nitric oxide (NO), asymmetric dimethylarginine (ADMA), and possibly symmetric dimethylarginine (SDMA) have been linked to the severity of the disease. We investigated whether plasma levels of dimethylarginines and NO are elevated in patients with hepatorenal syndrome (HRS), compared with patients with cirrhosis without renal failure (no- HRS). Plasma levels of NO, ADMA, SDMA, and L-arginine were measured in 11 patients with HRS, seven patients with no-HRS, and six healthy volunteers. SDMA concentration in HRS was higher than in no-HRS and healthy subjects (1.47 6 0.25 vs. 0.38 6 0.06 and 0.29 6 0.04 lM, respectively; P , 0.05). ADMA and NOx concentrations were higher in HRS and no-HRS patients than in healthy subjects (ADMA, 1.20 6 0.26, 1.11 6 0.1, and 0.53 6 0.06 lM, respectively; P , 0.05; NOx, 94 6 9.1, 95.5 6 9.54, and 37.67 6 4.62 lM, respectively; P , 0.05). In patients with HRS there was a positive correlation between serum creatinine and plasma SDMA (r2¼0.765, P , 0.001) but not between serum creatinine and ADMA or NOx. The results suggest that renal dysfunction is a main determinant of elevated SDMA concentration in HRS. Accumulation of ADMA as a result of impaired hepatic removal may be the causative factor initiating renal vasoconstriction and SDMA retention in the kidney. Exp Biol Med 231:70<br>75, 2006
dc.relation.ispartof Experimental Biology and Medicine, 2006, vol. 231, p. 70-75
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Lluch García, Paloma Mauricio Aviño, María Dolores Vila Salinas, José Maria Segarra Irles, Gloria Vicenta Medina Besso, Pascual Olmo Puchalt, Juan Angel del Rodrigo Gómez, José Manuel Serra Desfilis, Miguel Angel 2006 Accumulation of symetric dimethylarginine in hepatorenal syndrome. Experimental Biology and Medicine 231 70 75
dc.subject Medicina
dc.subject Patologia
dc.title Accumulation of symetric dimethylarginine in hepatorenal syndrome.
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-11-22T10:58:27Z
dc.identifier.idgrec 022493

View       (79.71Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics