Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide
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Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide

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Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide

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dc.contributor.author Víctor González, Víctor Manuel
dc.contributor.author Nuñez, Cristina
dc.contributor.author D'Ocon Navaza, Pilar
dc.contributor.author Cormac T., Taylor
dc.contributor.author Esplugues Mota, Juan Vicente
dc.contributor.author Salvador, Moncada
dc.date.accessioned 2011-08-19T09:15:11Z
dc.date.available 2011-08-19T09:15:11Z
dc.date.issued 2009
dc.identifier.uri http://hdl.handle.net/10550/20054
dc.description.abstract Nitric oxide (NO) decreases cellular oxygen (O2) consumption by competitively inhibiting cytochrome c oxidase. Here, we show that endogenously released endothelial NO, either basal or stimulated, can modulate O2 consumption both throughout the thickness of conductance vessels and in the microcirculation. Furthermore, we have shown that such modulation regulates O2 distribution to the surrounding tissues. We have demonstrated these effects by measuring O2 consumption in blood vessels in a hypoxic chamber and O2 distribution in the microcirculation using the fluorescent oxygen-probe Ru(phen)3^2+. Removal of NO by physical or pharmacological means, or in eNOS^¯/¯ mice, abolishes this regulatory mechanism. Our results indicate that, in addition to its well-known effect on the regulation of vascular tone, endothelial NO plays a major role in facilitating the distribution of O2, an action which is crucial for the adaptation of tissues, including the vessel wall itself, to hypoxia. It is possible that changes in the distribution of O2 throughout the vessel wall may be implicated in the origin of vascular pathologies such as atherosclerosis. en
dc.language.iso en en
dc.relation http://circres.ahajournals.org/cgi/reprint/104/10/1178 en
dc.source Víctor González, Víctor Manuel; Nuñez, Cristina ; d'Ocon Navaza, Maria Pilar ; Cormac T., Taylor , Esplugues Mota, Juan Vicente ; Salvador, Moncada, 2009, Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide, Circulation Research, vol. 104, no. 10, p. 1178-1183 en
dc.subject Nitric oxide ; Endothelium ; Oxygen consumption en
dc.title Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS ::Medicina interna en
dc.identifier.doi 10.1161/CIRCRESAHA.109.197228 en
dc.description.private Victor Gonzalez, Victor Manuel, Victor.Victor@uv.es ; d'Ocon Navaza, Maria Pilar, M.Pilar.Docon@uv.es ; Esplugues Mota, Juan Vicente, Juan.V.Esplugues@uv.es en
dc.identifier.idgrec 051285 en

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