Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)
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Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)

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Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae)

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dc.contributor.author Toledo Navarro, Rafael
dc.contributor.author Espert Fernandez, Ana M.
dc.contributor.author Muñoz Antoli-Candela, Carla Teresa
dc.contributor.author Marcilla Diaz, Antonio
dc.contributor.author Fried, Bernard
dc.contributor.author Esteban Sanchis, Jose Guillermo
dc.date.accessioned 2010-08-09T10:34:19Z
dc.date.available 2010-08-09T10:34:19Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10550/16775
dc.description.abstract The present study reports on the kinetics of antibodies and antigens in serum of mice experimentally infected with 75 metacercariae of Echinostoma caproni during the first 12 wk postinfection (wpi). Antibody titers in the serum of mice were determined by an indirect enzyme-linked immunosorbent assay (ELISA) using excretory/secretory (ES) antigens of E. caproni. The early detection of antibodies against ES antigens of E. caproni is feasible using indirect ELISA. Mice developed significant antibody responses at 2 wpi, and the values progressively increased until the end of the experiment. This may be related to the intestinal absorption of adult worm antigens that induces humoral responses. The presence of E. caproni circulating antigens was determined by a capture ELISA based on polyclonal rabbit antibodies against ES antigens of E. caproni. High levels of seroantigens in mice were detected by 1–2 wpi, probably because of the local inflammatory responses in mice induced by the adult worms. A drop in circulating antigen levels was observed at 9 wpi, which could reflect changes in the intestinal tissues over the course of the infection. en
dc.language.iso en en
dc.relation http://www.journalofparasitology.org/doi/pdf/10.1645/GE-461R.1 en
dc.source TOLEDO NAVARRO, Rafael ; Espert Fernandez, Ana M. ; Muñoz Antoli-Candela, Carla Teresa ; Marcilla Diaz, Antonio ; Fried, Bernard ; Esteban Sanchis, Jose Guillermo, 2005, Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (Trematoda: echinostomatidae), Journal of Parasitology, vol. 91, no. 4, p. 978–980 en
dc.subject Antibodies ; Antigens ; Echinostoma caproni en
dc.title Kinetics of antibodies and antigens in serum of mice experimentally infected with echinostoma caproni (trematoda: echinostomatidae) en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA en
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología) ::Parasitología animal en
dc.description.private Toledo Navarro, Rafael, Rafael.Toledo@uv.es ; Espert Fernandez, Ana M., Ana.M.Espert@uv.es ; Marcilla Diaz, Antonio, Antonio.Marcilla@uv.es ; Esteban Sanchis, Jose Guillermo, Jguillermo.Esteban@uv.es en
dc.identifier.idgrec 025476 en

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